Journal: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Article Title: NCI Alliance for Nanotechnology in Cancer – Catalysing Research and Translation Towards Novel Cancer Diagnostics and Therapeutics
doi: 10.1002/wnan.1570
Figure Lengend Snippet: Cumulative cancer clinical trials conducted for liposomal versus non-liposomal nanoparticles over time. This graph displays clinical trials performed for liposomal delivery systems (solid black bars – left axis) since the approval of Doxil in 1995. In comparison, all non-liposomal nanoparticle cancer clinical trials are displayed as solid blue fill, corresponding right axis. The information was derived from clinicaltrials.gov based on the following keyword searches ‘Cancer and – liposomal, Caelyx, Myocet, Lipodox, Onivyde, Depocyt, Daunoxome, Marquibo, Vyxeos, or Mepact’ and for non-liposomal ‘Cancer and nanoparticle or nanotechnology’. The nab-paclitaxel trials that were found were excluded from non-liposomal trials count. The year on the horizontal axis corresponds to the initiation of the trial.
Article Snippet: General Hospital ( Rai et al., 2010 ) Visudyne licensed to Bausch and Lomb Multifunctional nanoparticles in diagnosis and therapy of pancreatic cancer Paras Prasad SUNY-Buffalo ( Yong et al., 2009 ) Licensed to Nanobiotix Near-infrared fluorescence nanoparticles for targeted optical imaging Chun Li MD Anderson Cancer Center ( Zhang et al., 2011 ) Carestream Health DNA-linked dendrimer nanoparticle systems for cancer diagnosis and treatment James Baker University of Michigan ( Myc et al., 2010 ) Avidimer Hybrid nanoparticles in imaging and therapy of prostate cancer Kattesh Katti University of Missouri ( Chanda et al., 2010 ) Nanoparticle Biochem Inc. Open in a separate window Technologies developed by R01 and U01 awardees.
Techniques: Derivative Assay